Frame Shifts
A frame shift occurs when a gene is disrupted by addition or subtraction of nucleotides of a quantity not evenly divisible by three—the length of a codon. Sometimes this is due to an error in the sequencing process itself. A frame shift that is not the result of an error is called authentic.
g) added to it, and this changes the last few proteins in the red protein encoding gene. In the box below the two DNA sequences you can see how a frame shift would affect the Compare Regions display in the Genome Viewer, which shows similar genes in three close strain? genomes. The result of the frame shift is quite dramatic: all three regions start the same, but the third ends very differently.
Topic revision: r2 - 16 Jan 2009 - 15:06:49 - Bruce Parrello
Notice to NMPDR Users - The NMPDR BRC contract has ended and bacterial data from NMPDR has been transferred to PATRIC (http://www.patricbrc.org), a new consolidated BRC for all NIAID category A-C priority pathogenic bacteria. NMPDR was a collaboration among researchers from the Computation Institute of the University of Chicago, the Fellowship for Interpretation of Genomes (FIG), Argonne National Laboratory, and the National Center for Supercomputing Applications (NCSA) at the University of Illinois. NMPDR is funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract HHSN266200400042C. Banner images are copyright © Dennis Kunkel.