Protein encoding gene (PEG), protein coding sequence (CDS), and open reading frame (ORF) are synonymous terms. Protein encoding genes are commmonly described as structural or regulatory. Structural genes encode enzymes and structural proteins. Regulatory genes encode proteins that function to regulate the expression of other genes, often by binding specifically to short sequences of the DNA. PEGs may be labeled as hypothetical when there is an open reading frame, but no experimental evidence that the encoded protein is expressed, or no suggestion by homology of the function of the encoded protein.
Topic revision: r2 - 23 May 2008 - 08:20:56 - BruceParrello
NMPDR is a collaboration among researchers from the Computation Institute of the University of Chicago, the Fellowship for Interpretation of Genomes (FIG), Argonne National Laboratory, and the National Center for Supercomputing Applications (NCSA) at the University of Illinois. NMPDR is funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract HHSN266200400042C. Banner images are copyright © Dennis Kunkel.