Taxonomy: Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Campylobacteraceae;

Campylobacter

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Campylobacter jejuni

I. Organism Information

A. Taxonomy Information

1. Species

a. Campylobacter jejuni

i. Taxonomy ID: 197

ii. Description:

Campylobacter jejuni is a member of the epsilon group of proteobacteria and is Gram-negative, microaerophilic and motile. C. jejuni is the leading cause of bacterial food-borne diarrheal disease throughout the world (1). Humans acquire the organisms by eating undercooked chicken or drinking contaminated milk and water. During the course of infection, hosts show symptoms of fever, cramps, and bloody diarrhea. Campylobacter is an invasive pathogen that penetrates the lining of the small intestine. Upon entry, it excretes toxins that destroy the gut mucosa.

Public health awareness of Campylobacter infections has evolved over more than a century. In 1886, Escherich observed organisms resembling campylobacters in stool samples of children with diarrhea. In 1913, McFaydean and Stockman identified campylobacters. In 1957, King described the isolation of related Vibrio from blood samples of children with diarrhea, and in 1972, clinical microbiologists in Belgium first isolated campylobacters from stool samples of patients with diarrhea. The development of selective growth media in the 1970s permitted more laboratories to test stool specimens for Campylobacter, which were soon recognized as common human pathogens (2).

iii. Variants

Campylobacter jejuni RM1221
Taxonomy ID: 195099
Parent: Campylobacter jejuni

Campylobacter jejuni subsp. doylei
Taxonomy ID: 32021
Parent: Campylobacter jejuni

Campylobacter jejuni subsp. jejuni NCTC 11168
Taxonomy ID: 192222
Parent: Campylobacter jejuni

B. Lifecycle and Morphology

1. One stage

a. Shape:

Vibriod, slender, 0.2-0.5 μm by 0.5-5 μm, may have more than one helical turn. They may also appear S-shaped or gull-wing-shaped when two cells form short chains. Cells in old cutures may form spherical forms (coccoid bodies) (3).

b. Picture:

SEM of Campylobacter jejuni
SEM image of Campylobacter jejuni with size bar by Janice Carr, CDC

C. Genome Summary

1. Genome of Campylobacter jejuni

a. Chromosome of Campylobacter jejuni RM1221

i. Genbank Accession Number: NC_003912


ii. Size: 1,777,831 bp

b. Chromosome of Campylobacter jejuni subsp. jejuni NCTC 11168

i. Genbank Accession Number: NC_002163
ii. Size: 1,641,481 bp

c. Plasmid pCJ419

i. Genbank Accession Number: NC_004997


ii. Size: 4,013 bp

d. Plasmid pVir

i. Genbank Accession Number: NC_005012
ii. Size: 37,468 bp
iii. Description: This is a circular plasmid of Campylobacter jejuni strain 81-176 and has a GC content of 26%. A total of 83% of the plasmid represented coding information, and all but 2 of the 54 predicted open reading frames were encoded on the same DNA strand. Seven genes were found to be orthologs of type IV secretion proteins found in Helicobacter pylori. Seven other pVir-encoded proteins showed significant similarities to proteins encoded by the plasticity zones of either H. pylori J99 or 26695. Mutational analyses of 19 plasmid genes identified 5 additional genes that affect in vitro invasion of intestinal epithelial cells (4).

e. Plasmid pTet

i. Genbank Accession Number: NC_006135
ii. Size: 45,205 bp



II. References

1.  Parkhill J, Wren BW, Mungall K, Ketley JM, Churcher C, Basham D, Chillingworth T, Davies RM, Feltwell T, Holroyd S, Jagels K, Karlyshev AV, Moule S, Pallen MJ, Penn CW, Quail MA, Rajandream MA, Rutherford KM, van Vliet AH, Whitehead S, Barrell BG. (2000) The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature 403(6770):665-668.

2.  Altekruse SF, Stern NJ, Fields PI, Swerdlow DL. (1999) Campylobacter jejuni—An Emerging Foodborne Pathogen. Emerging Infectious Diseases 5(1): 28-35.

3.  Bergey's Manual of Determinative Bacteriology, 9th edition. John G. Holt, Noel R. Krieg, Peter H.A. Sneath, James T. Staley, and Stanley T. Williams, editors. Baltimore: Williams and Wilkins, 1994, p. 41

4.  Bacon DJ, Alm RA, Hu L, Hickey TE, Ewing CP, Batchelor RA, Trust TJ, Guerry P. (2002) DNA sequence and mutational analyses of the pVir plasmid of Campylobacter jejuni 81-176. Infect Immun. 70(11): 6242-6250.

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Campylobacter - Google News

©2017 Google

British retailers to self-report chicken Campylobacter results Food ... - Food Safety News


Food Safety News

British retailers to self-report chicken Campylobacter results Food ...
Food Safety News
England's top nine retail grocers are going to begin publishing results of the Campylobacter retail survey of fresh shop-bought chickens produced in the United ...
FSA drops top nine retailers from annual campylobacter survey ...FarmingUK
New rules for reporting life threatening chicken bug News The ...The Times

all 4 news articles »

CDC investigating Campylobacter outbreak linked to puppies - WTSP 10 News


Kansas City Star

CDC investigating Campylobacter outbreak linked to puppies
WTSP 10 News
The CDC reports 55 people have confirmed infections or symptoms consistent with Campylobacter infection. Florida, Kansas, Maryland, Missouri, New Hampshire, New York, Ohio, Pennsylvania, Tennessee, Utah, Wisconsin, and Wyoming all have confirmed ...
Puppies Linked To Bacterial Infection Outbreak Across 12 StatesForbes
Bacterial infection traced to Petland spreads and it's drug-resistantKansas City Star
Pet store puppies spreading antibiotic-resistant bacteria in FloridaLocal 10
Miami Herald -WebMD -Washington Post -Centers for Disease Control and Prevention
all 63 news articles »

FSA Survey Reveals Reduction of Campylobacter in Retail ... - ThePoultrySite.com


FoodQualityNews.com

FSA Survey Reveals Reduction of Campylobacter in Retail ...
ThePoultrySite.com
UK - The Food Standards Agency (FSA) yesterday published the last set of results from its survey of campylobacter contamination in fresh UK-produced ...
FSA: Campylobacter in chicken levels down - Food Quality NewsFoodQualityNews.com
PoultryWorld - Final FSA campylobacter stats show further fallsPoultry World
Campylobacter contamination falls to its lowest levels in yearsFoodManufacture.co.uk

all 5 news articles »

Germs in the kitchen: Salmonella better known than Campylobacter ... - EurekAlert (press release)


Germs in the kitchen: Salmonella better known than Campylobacter ...
EurekAlert (press release)
What health risks are consumers aware of? What are they concerned about? The answers to these questions are provided by the BfR Consumer Monitor, ...

and more »

CDC Expands Investigation of Human Campylobacter Infections ... - PetProductNews.com


PetProductNews.com

CDC Expands Investigation of Human Campylobacter Infections ...
PetProductNews.com
The CDC has expanded its investigation of a multistate outbreak of human Campylobacter infections linked to puppies sold through Petland, a national pet store ...
Puppy poop infections now affecting 12 statesChicago Tribune
Pet store puppies spread antibiotic-resistant infection, CDC sayskfor.com
More illnesses linked to pet store puppies - CBS NewsCBS News
KFVS -CBS Baltimore / WJZ -MyAJC
all 19 news articles »

One in three M&S chickens test positive for deadly food-poisoning ... - The Sun


The Sun

One in three M&S chickens test positive for deadly food-poisoning ...
The Sun
Nearly two thirds of M&S chickens test positive for food bug says watchdog.

and more »

Pet store puppies cause big bacteria outbreak The Johns Hopkins ... - Johns Hopkins News-Letter


Pet store puppies cause big bacteria outbreak The Johns Hopkins ...
Johns Hopkins News-Letter
They've infiltrated our homes and our hearts: 44 percent of Americans own dogs and enjoy taking their wet-nosed best friends on routine walks and pampering ...

and more »

The $3500 question: Should Petland refund all costs of dog with nasty infection? - Kansas City Star


Kansas City Star

The $3500 question: Should Petland refund all costs of dog with nasty infection?
Kansas City Star
Like most puppies, Zigg just wants to show his owner some love. But every time the Victorian bulldog tries to lick Raymore resident Brenda Douglas in the face, she jerks her head away violently. Her health depends on it. Zigg has Campylobacter, a ...

Projected Campylobacter increase in Belgium prompts call for action - FoodQualityNews.com


FoodQualityNews.com

Projected Campylobacter increase in Belgium prompts call for action
FoodQualityNews.com
Efforts to control cases of salmonellosis and listeriosis in Belgium must be maintained in the future whereas new actions are urgently needed to understand and reduce the risk of food being contaminated with Campylobacter spp, said researchers.

CDC Issues Report About 2016 Campylobacter Outbreak in Clark County, WA - Food Poisoning Bulletin


Food Poisoning Bulletin

CDC Issues Report About 2016 Campylobacter Outbreak in Clark County, WA
Food Poisoning Bulletin
A Campylobacter outbreak in Clark County, Washington in 2016 was associated with undercooked chicken liver mousse. The Centers for Disease Control and Prevention (CDC) issued a Notes from the Field about that outbreak in last week's Morbidity and ...

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Virtual structural proteome: browse a table of all Campy proteins with entries or homologs in PDB

Campylobacter genome sequence annotation status: click numbers to browse lists of genes or subsystems

Strain annotated in NMPDR Genome size, bp Protein Encoding Genes (PEGs) Sort Named genes in subsystems Named genes not in subsystems Hypothetical genes in subsystems Hypothetical genes not in subsystems Subsystems RNAs
Campylobacter coli RM2228 1,860,666 1,965 925(45.8%) 608(30.1%) 26(1.3%) 459(22.7%) 270 56
Campylobacter concisus 13826 2,099,413 2,094 767(35.7%) 743(34.6%) 21(1.0%) 618(28.8%) 218 101
Campylobacter curvus 525.92 1,971,264 2,063 822(38.8%) 761(35.9%) 21(1.0%) 514(24.3%) 223 101
Campylobacter fetus subsp. fetus 82-40 1,773,615 1,732 874(50.3%) 515(29.7%) 22(1.3%) 325(18.7%) 276 52
Campylobacter hominis ATCC BAA-381 1,714,951 1,744 681(39.0%) 490(28.0%) 15(0.9%) 561(32.1%) 232 55
Campylobacter jejuni RM1221 1,777,831 1,838 885(47.0%) 566(30.0%) 23(1.2%) 410(21.8%) 270 53
Campylobacter jejuni subsp. doylei 269.97 1,845,106 2,094 879(40.9%) 776(36.1%) 22(1.0%) 470(21.9%) 234 97
Campylobacter jejuni subsp. jejuni 260.94 1,657,846 1,718 907(51.4%) 580(32.8%) 27(1.5%) 252(14.3%) 259 102
Campylobacter jejuni subsp. jejuni 81-176 1,699,052 1,748 866(49.4%) 569(32.5%) 37(2.1%) 280(16.0%) 257 56
Campylobacter jejuni subsp. jejuni 84-25 1,671,624 1,749 916(51.0%) 592(32.9%) 25(1.4%) 264(14.7%) 262 51
Campylobacter jejuni subsp. jejuni CF93-6 1,676,304 1,758 918(50.8%) 604(33.4%) 24(1.3%) 260(14.4%) 260 51
Campylobacter jejuni subsp. jejuni HB93-13 1,694,788 1,712 875(51.0%) 558(32.5%) 27(1.6%) 257(15.0%) 260 63
Campylobacter jejuni subsp. jejuni NCTC 11168 1,641,481 1,633 866(52.9%) 538(32.9%) 25(1.5%) 208(12.7%) 272 101
Campylobacter lari RM2100 1,562,926 1,594 843(51.3%) 500(30.4%) 21(1.3%) 279(17.0%) 258 53
Campylobacter upsaliensis RM3195 1,773,834 1,930 881(44.5%) 542(27.4%) 22(1.1%) 534(27.0%) 267 51
Topic revision: r9 - 20 Jan 2009 - 10:21:24 - TWiki Guest
 
Notice to NMPDR Users - The NMPDR BRC contract has ended and bacterial data from NMPDR has been transferred to PATRIC (http://www.patricbrc.org), a new consolidated BRC for all NIAID category A-C priority pathogenic bacteria. NMPDR was a collaboration among researchers from the Computation Institute of the University of Chicago, the Fellowship for Interpretation of Genomes (FIG), Argonne National Laboratory, and the National Center for Supercomputing Applications (NCSA) at the University of Illinois. NMPDR is funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract HHSN266200400042C. Banner images are copyright © Dennis Kunkel.