Taxonomy: Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Campylobacteraceae;

Campylobacter

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Campylobacter jejuni

I. Organism Information

A. Taxonomy Information

1. Species

a. Campylobacter jejuni

i. Taxonomy ID: 197

ii. Description:

Campylobacter jejuni is a member of the epsilon group of proteobacteria and is Gram-negative, microaerophilic and motile. C. jejuni is the leading cause of bacterial food-borne diarrheal disease throughout the world (1). Humans acquire the organisms by eating undercooked chicken or drinking contaminated milk and water. During the course of infection, hosts show symptoms of fever, cramps, and bloody diarrhea. Campylobacter is an invasive pathogen that penetrates the lining of the small intestine. Upon entry, it excretes toxins that destroy the gut mucosa.

Public health awareness of Campylobacter infections has evolved over more than a century. In 1886, Escherich observed organisms resembling campylobacters in stool samples of children with diarrhea. In 1913, McFaydean and Stockman identified campylobacters. In 1957, King described the isolation of related Vibrio from blood samples of children with diarrhea, and in 1972, clinical microbiologists in Belgium first isolated campylobacters from stool samples of patients with diarrhea. The development of selective growth media in the 1970s permitted more laboratories to test stool specimens for Campylobacter, which were soon recognized as common human pathogens (2).

iii. Variants

Campylobacter jejuni RM1221
Taxonomy ID: 195099
Parent: Campylobacter jejuni

Campylobacter jejuni subsp. doylei
Taxonomy ID: 32021
Parent: Campylobacter jejuni

Campylobacter jejuni subsp. jejuni NCTC 11168
Taxonomy ID: 192222
Parent: Campylobacter jejuni

B. Lifecycle and Morphology

1. One stage

a. Shape:

Vibriod, slender, 0.2-0.5 μm by 0.5-5 μm, may have more than one helical turn. They may also appear S-shaped or gull-wing-shaped when two cells form short chains. Cells in old cutures may form spherical forms (coccoid bodies) (3).

b. Picture:

SEM of Campylobacter jejuni
SEM image of Campylobacter jejuni with size bar by Janice Carr, CDC

C. Genome Summary

1. Genome of Campylobacter jejuni

a. Chromosome of Campylobacter jejuni RM1221

i. Genbank Accession Number: NC_003912


ii. Size: 1,777,831 bp

b. Chromosome of Campylobacter jejuni subsp. jejuni NCTC 11168

i. Genbank Accession Number: NC_002163
ii. Size: 1,641,481 bp

c. Plasmid pCJ419

i. Genbank Accession Number: NC_004997


ii. Size: 4,013 bp

d. Plasmid pVir

i. Genbank Accession Number: NC_005012
ii. Size: 37,468 bp
iii. Description: This is a circular plasmid of Campylobacter jejuni strain 81-176 and has a GC content of 26%. A total of 83% of the plasmid represented coding information, and all but 2 of the 54 predicted open reading frames were encoded on the same DNA strand. Seven genes were found to be orthologs of type IV secretion proteins found in Helicobacter pylori. Seven other pVir-encoded proteins showed significant similarities to proteins encoded by the plasticity zones of either H. pylori J99 or 26695. Mutational analyses of 19 plasmid genes identified 5 additional genes that affect in vitro invasion of intestinal epithelial cells (4).

e. Plasmid pTet

i. Genbank Accession Number: NC_006135
ii. Size: 45,205 bp



II. References

1.  Parkhill J, Wren BW, Mungall K, Ketley JM, Churcher C, Basham D, Chillingworth T, Davies RM, Feltwell T, Holroyd S, Jagels K, Karlyshev AV, Moule S, Pallen MJ, Penn CW, Quail MA, Rajandream MA, Rutherford KM, van Vliet AH, Whitehead S, Barrell BG. (2000) The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature 403(6770):665-668.

2.  Altekruse SF, Stern NJ, Fields PI, Swerdlow DL. (1999) Campylobacter jejuni—An Emerging Foodborne Pathogen. Emerging Infectious Diseases 5(1): 28-35.

3.  Bergey's Manual of Determinative Bacteriology, 9th edition. John G. Holt, Noel R. Krieg, Peter H.A. Sneath, James T. Staley, and Stanley T. Williams, editors. Baltimore: Williams and Wilkins, 1994, p. 41

4.  Bacon DJ, Alm RA, Hu L, Hickey TE, Ewing CP, Batchelor RA, Trust TJ, Guerry P. (2002) DNA sequence and mutational analyses of the pVir plasmid of Campylobacter jejuni 81-176. Infect Immun. 70(11): 6242-6250.

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Campylobacter - Google News

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Campylobacter colonization is not associated with proventricular dilatation disease in psittacines - Dove Medical Press


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Public Health Wales is notified of between 3,000 and 4,000 cases of Campylobacter every year. Dr Brendan Mason, consultant in communicable disease control for Public Health Wales, said: If you have consumed Penlan y M r unpasteurised milk any time ...

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Akeso patent looks to offer antibiotic-free alternative for campylobacter reduction - FeedNavigator.com


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Akeso patent looks to offer antibiotic-free alternative for campylobacter reduction
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The awarded patent covers the use of Akeso's ferric tyrosine (Fe3C) technology in poultry feed or water to reduce the presence of campylobacter, said Jerome Meier, chief operating officer with Akeso. It also covers use of the technology for a portion ...

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Campylobacter, Salmonella and norovirus cause most illnesses in France
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Campylobacter outbreak, Additional measles case reported in Wales - Outbreak News Today


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Campylobacter outbreak, Additional measles case reported in Wales
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Health officials in Wales are reporting on a Campylobacter outbreak linked to unpasteurized or 'raw' cow's milk produced at Penlan y M r Farm near New Quay. Visitors to the Royal Welsh Show in Builth Wells may have sampled or bought the milk, which was ...

Campylobacter levels cut by joined-up effort - Poultry World (subscription)


Poultry World (subscription)

Campylobacter levels cut by joined-up effort
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The amount of progress can be seen by looking at historic levels of campylobacter. The Food Standards Agency (FSA) carried out a survey of campylobacter in chicken on retail sale between May 2007 and September 2008 and found it was present on 65% of ...

Akeso Biomedical Advances Technology to Reduce Foodborne Illness; Receives New Patent to Reduce ... - Business Wire (press release)


Akeso Biomedical Advances Technology to Reduce Foodborne Illness; Receives New Patent to Reduce ...
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The Company has been awarded a new U.S Patent that represents a significant step forward in reducing the incidence of foodborne illness due to infection by the bacterium, Campylobacter. Akeso Biomedical is a privately held company developing novel, ...

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The Guillain Barr peptide signatures: from Zika virus to Campylobacter, and beyond - Dove Medical Press


The Guillain Barr peptide signatures: from Zika virus to Campylobacter, and beyond
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Abstract: Scientific attention has focused recently on the link between Guillain Barr syndrome (GBS) and Zika virus (ZIKV). Two related questions emerged: 1) what triggered the violent 2014 outbreak of a virus, which, first identified in 1947, had ...

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Virtual structural proteome: browse a table of all Campy proteins with entries or homologs in PDB

Campylobacter genome sequence annotation status: click numbers to browse lists of genes or subsystems

Strain annotated in NMPDR Genome size, bp Protein Encoding Genes (PEGs) Sort Named genes in subsystems Named genes not in subsystems Hypothetical genes in subsystems Hypothetical genes not in subsystems Subsystems RNAs
Campylobacter coli RM2228 1,860,666 1,965 925(45.8%) 608(30.1%) 26(1.3%) 459(22.7%) 270 56
Campylobacter concisus 13826 2,099,413 2,094 767(35.7%) 743(34.6%) 21(1.0%) 618(28.8%) 218 101
Campylobacter curvus 525.92 1,971,264 2,063 822(38.8%) 761(35.9%) 21(1.0%) 514(24.3%) 223 101
Campylobacter fetus subsp. fetus 82-40 1,773,615 1,732 874(50.3%) 515(29.7%) 22(1.3%) 325(18.7%) 276 52
Campylobacter hominis ATCC BAA-381 1,714,951 1,744 681(39.0%) 490(28.0%) 15(0.9%) 561(32.1%) 232 55
Campylobacter jejuni RM1221 1,777,831 1,838 885(47.0%) 566(30.0%) 23(1.2%) 410(21.8%) 270 53
Campylobacter jejuni subsp. doylei 269.97 1,845,106 2,094 879(40.9%) 776(36.1%) 22(1.0%) 470(21.9%) 234 97
Campylobacter jejuni subsp. jejuni 260.94 1,657,846 1,718 907(51.4%) 580(32.8%) 27(1.5%) 252(14.3%) 259 102
Campylobacter jejuni subsp. jejuni 81-176 1,699,052 1,748 866(49.4%) 569(32.5%) 37(2.1%) 280(16.0%) 257 56
Campylobacter jejuni subsp. jejuni 84-25 1,671,624 1,749 916(51.0%) 592(32.9%) 25(1.4%) 264(14.7%) 262 51
Campylobacter jejuni subsp. jejuni CF93-6 1,676,304 1,758 918(50.8%) 604(33.4%) 24(1.3%) 260(14.4%) 260 51
Campylobacter jejuni subsp. jejuni HB93-13 1,694,788 1,712 875(51.0%) 558(32.5%) 27(1.6%) 257(15.0%) 260 63
Campylobacter jejuni subsp. jejuni NCTC 11168 1,641,481 1,633 866(52.9%) 538(32.9%) 25(1.5%) 208(12.7%) 272 101
Campylobacter lari RM2100 1,562,926 1,594 843(51.3%) 500(30.4%) 21(1.3%) 279(17.0%) 258 53
Campylobacter upsaliensis RM3195 1,773,834 1,930 881(44.5%) 542(27.4%) 22(1.1%) 534(27.0%) 267 51
Topic revision: r9 - 20 Jan 2009 - 10:21:24 - TWiki Guest
 
Notice to NMPDR Users - The NMPDR BRC contract has ended and bacterial data from NMPDR has been transferred to PATRIC (http://www.patricbrc.org), a new consolidated BRC for all NIAID category A-C priority pathogenic bacteria. NMPDR was a collaboration among researchers from the Computation Institute of the University of Chicago, the Fellowship for Interpretation of Genomes (FIG), Argonne National Laboratory, and the National Center for Supercomputing Applications (NCSA) at the University of Illinois. NMPDR is funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract HHSN266200400042C. Banner images are copyright © Dennis Kunkel.