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Streptococcus
I. Organism Information
A. Taxonomy Information
1. Species
a. S. pyogenes
i. Taxonomy ID: 1314
ii. Description:
Streptococcus pyogenes, also known as Group A Streptococcus (GAS) is a Gram-positive, nonmotile, coccus that does not form spores. Because they divide in one plane, they occur in pairs or in chains of various lengths. GAS ferments glucose to lactate. GAS is a catalase-negative facultative anaerobe, and requires enriched medium containing blood in order to grow. GAS are shielded by a nonantigenic capsule composed of hyaluronic acid that surrounds the cell wall and is penetrated by the M protein. GAS exhibits beta (complete, clear) hemolysis on blood agar. (1)
To contribute a blurb on serotypes or handling the organism in healthcare or laboratory facilities, please contact help@nmpdr.org Your contribution will be credited with a byline.
iii. Variants
Streptococcus pyogenes serotype M1
Taxonomy ID: 301447
Streptococcus pyogenes serotype M2
Taxonomy ID: 404330
Streptococcus pyogenes serotype M3
Taxonomy ID: 301448
Streptococcus pyogenes serotype M4
Streptococcus pyogenes serotype M5
Taxonomy ID: 301449
Streptococcus pyogenes serotype M6
Taxonomy ID: 301450
Streptococcus pyogenes serotype M12
Taxonomy ID: 342023
Streptococcus pyogenes serotype M18>
Taxonomy ID: 301451
Streptococcus pyogenes serotype M28
Taxonomy ID: 319700
b. S. pneumoniae
i. Taxonomy ID: 1313
ii. Description:
Streptococcus pneumoniae, also known as pneumococcus, is a Gram-positive, nonmotile coccus that does not form spores. Pneumococcus is naturally competent to take up extracellular DNA. Like other Streptococci, pneumococcus ferments glucose to lactate, is a catalase-negative facultative anaerobe, and requires enriched medium containing blood in order to grow. A noninflammatory polysaccharide capsule shields the cell wall, which is composed of of peptidoglycan with teichoic acid and lipoteichoic acid. Pneumococcus exhibits alpha (partial, green) hemolysis on blood agar, but switches to beta (complete, clear) hemolysis under anaerobic conditions. There are 90 distinct serotypes of pneumococcus, of which types 6, 14, 18, 19, and 23 are most prevalent. (prokaryotes)
To contribute a blurb on phenotypes or handling the organism in healthcare or laboratory facilities, please contact help@nmpdr.org Your contribution will be credited with a byline.
iii. Variants
Streptococcus pneumoniae R6
Taxonomy ID: 171101
Streptococcus pneumoniae TIGR4
Taxonomy ID: 170187
B. Lifecycle and Morphology
1. S. pyogenes
a. Shape:
Lancet-shaped (slightly pointed) cocci 0.5-1.2 μm in diameter. Cells occur in pairs and short chains. Division is in one plane. Colonies are smooth, raised, circular, entire, and spontaneously undergo a phase variation from opaque to transparent, or glossy to matt. Single colonies may obtain a size of 1 mm in diameter.
b. Picture:
SEM of an ultra-thin section of two group A streptococci from a chain of cells. The septum between the two cells is clearly indicated by the light colored diagonal line in the center of the image. The bacterial chromosome is also clearly seen as the light staining material in the cell interior. Fibrils on the cell surface contain the type-specific M protein characteristic of S. pyogenes. (magnified 16000 x) By Maria Fazio, Rockefeller University
2. S. pneumoniae
a. Shape:
Lancet-shaped (slightly pointed) cocci 0.5-1.2 μm in diameter. Cells occur in pairs and short chains. Division is in one plane. Colonies are smooth, raised, circular, entire, and spontaneously undergo a phase variation from opaque to transparent, or glossy to matt. Single colonies may obtain a size of 1 mm in diameter.
b. Picture:
SEM a pair of encapsulated pneumococci, by Janice Carr, CDC
C. Genome Summary
1. Genome of Streptococcus pyogenes M1 GAS strain SF370
a. Chromosome
i. RefSeq Accession Number: NC_002737
ii. Size: 1,852,441 bp
iii. M1 serotype.
2. Genome of Streptococcus pyogenes MGAS5005
a. Chromosome
i. RefSeq Accession Number: NC_007297
ii. Size: 1,838,554 bp
iii. M1 serotype.
3. Genome of Streptococcus pyogenes MGAS10270
a. Chromosome
i. RefSeq Accession Number: NC_008022
ii. Size: 1,928,252 bp
iii. M2 serotype.
4. Genome of Streptococcus pyogenes MGAS315
a. Chromosome
i. RefSeq Accession Number: NC_004070
ii. Size: 1,900,521 bp
iii. M3 serotype.
5. Genome of Streptococcus pyogenes SSI-1
a. Chromosome
i. RefSeq Accession Number: NC_004606
ii. Size: 1,894,275 bp
iii. M3 serotype.
6. Genome of Streptococcus pyogenes MGAS10750
a. Chromosome
i. RefSeq Accession Number: NC_008024
ii. Size: 1,937,111 bp
iii. M4 serotype.
7. Genome of Streptococcus pyogenes Manfredo
a. Chromosome
i. RefSeq Accession Number: unavailable
ii. Size: 1,841,271 bp
iii. M5 serotype.
8. Genome of Streptococcus pyogenes MGAS10394
a. Chromosome
i. RefSeq Accession Number: NC_006086
ii. Size: 1,899,877 bp
iii. M6 serotype.
9. Genome of Streptococcus pyogenes MGAS2096
a. Chromosome
i. RefSeq Accession Number: NC_008023
ii. Size: 1,860,355 bp
iii. M12 serotype.
10. Genome of Streptococcus pyogenes MGAS9429
a. Chromosome
i. RefSeq Accession Number: NC_8021
ii. Size: 1,836,467 bp
iii. M12 serotype.
11. Genome of Streptococcus pyogenes MGAS8232
a. Chromosome
i. RefSeq Accession Number: NC_003485
ii. Size: 1,895,017 bp
iii. M18 serotype.
12. Genome of Streptococcus pyogenes MGAS6180
a. Chromosome
i. Genbank Accession Number: NC_007296
ii. Size: 1,897,573 bp
iii. M28 serotype.
II. References
1. http://textbookofbacteriology.net/streptococcus.html
2. http://bioresearch.ac.uk/browse/mesh/D013297.html
3. Ferretti JJ, McShan WM, Ajdic D, Savic DJ, Savic G, Lyon K, Primeaux C, Sezate S, Suvorov AN, Kenton S, Lai HS, Lin SP, Qian Y, Jia HG, Najar FZ, Ren Q, Zhu H, Song L, White J, Yuan X, Clifton SW, Roe BA, McLaughlin R. Complete genome sequence of an M1 strain of Streptococcus pyogenes. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4658-63.
5. Beres SB, Sylva GL, Barbian KD, Lei B, Hoff JS, Mammarella ND, Liu MY, Smoot JC, Porcella SF, Parkins LD, Campbell DS, Smith TM, McCormick JK, Leung DY, Schlievert PM, Musser JM. Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10078-83.
6. Smoot JC, Barbian KD, Van Gompel JJ, Smoot LM, Chaussee MS, Sylva GL, Sturdevant DE, Ricklefs SM, Porcella SF, Parkins LD, Beres SB, Campbell DS, Smith TM, Zhang Q, Kapur V, Daly JA, Veasy LG, Musser JM. Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4668-73.
7. Nakagawa I, Kurokawa K, Yamashita A, Nakata M, Tomiyasu Y, Okahashi N, Kawabata S, Yamazaki K, Shiba T, Yasunaga T, Hayashi H, Hattori M, Hamada S. Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution. Genome Res. 2003 Jun;13(6A):1042-55.
1. Hoskins J, Alborn WE Jr, Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR Jr, Skatrud PL, Glass JI. Genome of the bacterium Streptococcus pneumoniae strain R6. J Bacteriol. 2001 Oct;183(19):5709-17.
2. Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM. Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science. 2001 Jul 20;293(5529):498-506.
3. Oggioni MR, Iannelli F, Pozzi G. Characterization of cryptic plasmids pDP1 and pSMB1 of Streptococcus pneumoniae. Plasmid. 1999 Jan;41(1):70-2
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