Taxonomy: Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae;

Treponema

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Treponema

I. Organism Information

A. Taxonomy Information

1. Species

a. Treponema pallidum

i. Taxonomy ID: 157

ii. Description:

Treponema pallidum is a motile spirochaete that is generally acquired by close sexual contact and can also be transmitted to a fetus during the later stages of pregnancy, giving rise to congenital syphilis. The helical structure of T. pallidum allows it to move in a corkscrew motion through viscous mediums such as mucus. It gains access to host's blood and lymph systems through tissue and mucus membranes. Treponema pallidum subsp. pallidum has one of the smallest bacterial genomes at 1.14 million base pairs (Mb) and has limited metabolic capabilities, reflecting its adaptation through genome reduction to the rich environment of inside a host.


iii. Variants

Treponema pallidum subsp. pallidum str. Nichols
Taxonomy ID: 243276


II. References

1.  Lafond RE, Lukehart SA. Biological basis for syphilis. Clin Microbiol Rev. 2006 Jan;19(1):29-49.

2. Peeling RW, Hook EW 3rd. The pathogenesis of syphilis: the Great Mimicker, revisited. J Pathol. 2006 Jan;208(2):224-32.

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syphilis - Google News

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On one highway, drivers are getting warned about a 'syphilis tsunami' - Miami Herald


On one highway, drivers are getting warned about a 'syphilis tsunami'
Miami Herald
The foundation has apparently found it necessary in today's media and advertising landscape to take its campaign to eliminate AIDS, syphilis and other sexually transmitted diseases old-school via a giant jarring message 42.5 feet in the air on a ...

Lee County Reports a Spike in Syphilis Cases - WGCU News


WGCU News

Lee County Reports a Spike in Syphilis Cases
WGCU News
So far this year, Lee County has 106 cases of confirmed early syphilis which means a person was infected within a year before testing positive as opposed to the 92 cases for all of 2016. Syphilis is a sexually transmitted disease or STD. Area 8 STD ...

Lee County, Florida sees spike in syphilis cases - The News-Press - The News-Press


The News-Press

Lee County, Florida sees spike in syphilis cases - The News-Press
The News-Press
The Florida Department of Health in Lee County is warning the medical community and the public about a spike in reported cases of syphilis over the last year.

and more »

Tuskegee Syphilis Study: How Americans Learned What Happened ... - TIME


TIME

Tuskegee Syphilis Study: How Americans Learned What Happened ...
TIME
On July 25, 1972, the public learned that, over the course of the previous 40 years, a government medical experiment conducted in the Tuskegee, Ala., area had ...
Tuskegee Syphilis Study 45 years later: Its repercussions are still felt ...USA TODAY

all 2 news articles »

The Secret Story of How a Revered Future Surgeon General Inspired the Tuskegee Syphilis Study - Daily Beast


Daily Beast

The Secret Story of How a Revered Future Surgeon General Inspired the Tuskegee Syphilis Study
Daily Beast
The lost story of how a future surgeon general and revered medical figure inspired the most notorious and perhaps also the most unethical medical study in American history one in which African Americans were infected with syphilis and left untreated ...

Scalp Nodularity Associated with Secondary Syphilis - Infectious Disease Advisor (registration)


Infectious Disease Advisor (registration)

Scalp Nodularity Associated with Secondary Syphilis
Infectious Disease Advisor (registration)
The patient was referred 1 month later with papillary nodules at his right nasolabial fold and bilateral nasal vestibules, with condyloma lata around the anus. HealthDay News A rare case of secondary syphilis which primarily presented with multiple ...

Minnesota STD Rates Rising - WDIO-TV


Minnesota STD Rates Rising
WDIO-TV
According to MDH, chlamydia, gonorrhea and syphilis collectively rose 10 percent between 2015 and 2016. "Chlamydia and Gonorrhea have been on the rise for a long time," MDH Epidemiologist Ellen Hill said. "Syphilis has been noticeably on the rise for ...

HIV/Syphilis Test Kit to pilot in Tonga - ReliefWeb


HIV/Syphilis Test Kit to pilot in Tonga
ReliefWeb
21st August 2017 The duo HIV and Syphilis Test Kit will be piloted in Tonga in the next three months. Obstetrics and Gynecology Specialist Dr. Ma'ake Tupou is currently facilitating a one-day training at the Tanoa Hotel aiming to train Medical Officers ...

Syphilis outbreak plagues Mille Lacs Band - Detroit Lakes Online


Syphilis outbreak plagues Mille Lacs Band
Detroit Lakes Online
Syphilis cases in Minnesota increased by 30 percent between 2015-16. In 2016, 852 cases of syphilis were reported, with six cases of congenital syphilis. For 2017, 42 cases were associated with an outbreak in Mille Lacs County first identified in January.

Tuskegee Syphilis Experiment Discovered 45 Years Ago - TeenVogue.com


TeenVogue.com

Tuskegee Syphilis Experiment Discovered 45 Years Ago
TeenVogue.com
But on July 25, 1972, the public learned that doctors in Alabama had violated that oath in what's now known as the Tuskegee Syphilis Experiment. In 1932, the federal Public Health Service along with the Tuskegee Institute, a historically black college ...

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Treponema genome sequence annotation status: click numbers to browse lists of genes or subsystems

Strain annotated in NMPDR Genome size, bp Protein Encoding Genes (PEGs) Sort Named genes in subsystems Named genes not in subsystems Hypothetical genes in subsystems Hypothetical genes not in subsystems Subsystems RNAs
Treponema denticola ATCC 35405 2,843,201 2,769 717(25.4%) 983(34.8%) 9(0.3%) 1119(39.6%) 251 52
Treponema pallidum subsp. pallidum str. Nichols 1,138,011 1,057 454(41.4%) 564(51.4%) 1(0.1%) 78(7.1%) 183 82

Topic revision: r3 - 02 Mar 2009 - 00:03:21 - TWiki Guest
 
Notice to NMPDR Users - The NMPDR BRC contract has ended and bacterial data from NMPDR has been transferred to PATRIC (http://www.patricbrc.org), a new consolidated BRC for all NIAID category A-C priority pathogenic bacteria. NMPDR was a collaboration among researchers from the Computation Institute of the University of Chicago, the Fellowship for Interpretation of Genomes (FIG), Argonne National Laboratory, and the National Center for Supercomputing Applications (NCSA) at the University of Illinois. NMPDR is funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract HHSN266200400042C. Banner images are copyright © Dennis Kunkel.